What we love about SS-31:
SS-31 is a peptide that was introduced to and suggested for trial as it targets the root of cellular health, which is going to positively impact every aspect of the body whether for healing, anti-aging, or immunity. This is not a peptide that a person would “feel” immediately (such as BPC-157), but it has a long-term anti-aging benefit that may benefit every aspect of the human body.
Overview
People frequently face a variety of health difficulties as they age, which can have a substantial impact on their overall well-being. One significant aspect is mitochondria’s essential involvement in cellular metabolism. Disruptions in mitochondrial function can cause a variety of health difficulties, making it important to develop effective remedies for a higher quality of life. Here’s where SS-31 may help as it is a promising peptide with the potential to improve your overall health and well-being. Let’s take a look at what this peptide has to offer.
What’s SS-31
SS-31 also known as Elampretide, is a synthetic tetrapeptide developed to reduce the production of harmful reactive oxygen species (ROS) in the body with considerable potential in shielding and repairing damaged mitochondria. s notable efficacy extends to potentially preventing perioperative neurocognitive disorder (PND), a condition characterized by cognitive and behavioral changes that may occur post-surgery and anesthesia, particularly among older adults.
How Does SS-31 Work?
Mitochondria can be viewed as a “cell battery,” generating the energy needed for diverse cellular activities. hen mitochondria malfunction, it can lead to a range of inherited mitochondrial diseases and certain age-related conditions. Moreover, dysfunctional mitochondria produce elevated levels of oxidative factors that pose a significant threat to cardiolipin, a crucial lipid responsible for maintaining the structural integrity of mitochondria.
SS-31 intervenes by binding to cardiolipin, safeguarding it from the harmful impact of oxidative stress. This protective action serves to prevent or minimize dysfunction in mitochondrial membranes and cell death. Furthermore, the shielding effects of SS-31 on mitochondria contribute to the restoration of various essential cellular processes.
A study focused on LPS (lipopolysaccharide)-induced inflammation and oxidative stress, which resulted in learning and memory difficulties. LPS is a component of the cell wall that triggers the body’s immune response to infections, potentially causing cell death, inflammation, and oxidative stress. SS-31 demonstrates impressive capabilities in counteracting the effects of LPS.
Benefits of SS-31
Improved Function of Mitochondria
SS-31 can be helpful in protecting the brain against mitochondrial malfunction. The mitochondrial membrane potential (MMP) indicates mitochondrial activity. Adenosine triphosphate (ATP) is the energy produced by mitochondria and serves as the primary fuel source for cell function.
MMP is essential not just for cellular communication but also for ATP exchange. When MMP is low, cells may receive erroneous signals, resulting in a reduction in ATP function. SS-31 helps to maintain appropriate MMP and ATP levels, which contributes to the preservation of cell structure.
Lowers Inflammation and Oxidative Stress
Oxidative stress is caused by an imbalance between reactive oxygen species (ROS) and the body’s cellular antioxidant defenses. When ROS is not properly managed, it can cause cellular harm. Due to its high energy use, the brain produces higher quantities of ROS.
Unfortunately, the brain’s antioxidant defense is rather poor, leaving it vulnerable to oxidative injury. This sensitivity causes oxidative stress, which is linked to inflammation and can exacerbate cell damage. SS-31 acts by decreasing ROS, which suppresses the inflammatory response in the body.
Counteracts Cell Death
When cells produce an excessive amount of reactive oxygen species (ROS), it can impair electron transport, potentially triggering membrane depolarization and cell death. SS-31 is vital for removing ROS and inhibiting the onset of cell death pathways. This preventive activity helps to prevent mitochondrial malfunction.
Other Benefits of SS-31
Because of its ability to increase and prevent mitochondrial malfunction, SS-31 has the potential to treat a variety of ailments, including:
- Diabetes
- Cancer
- Muscular diseases
- Cardiovascular disease
- Traumatic Brain Injury (TBI)
- Aging process
Side-Effecs of SS-31
Thanks to numerous human clinical trials, both Phase 1 and Phase 2, we have gained insights into the anticipated side effects of SS-31. Most peptide injections, including SS-31, tend to result in infrequent and mild outcomes such as:
- Dizziness
- Headache
- Mild redness/swelling at the site of injection
These effects were consistent across various conditions for which SS-31 was studied and regardless of the formulation used (oral, intravenous, subcutaneous). No deaths were reported, serious adverse events were minimal, and the incidence of side effects in subjects taking SS-31 was comparable to those taking a placebo.
However, two important considerations should be noted:
- The long-term effects of taking SS-31 every day for more than four weeks are unknown.
- Some people who used SS-31 to treat chronic fatigue and raise energy levels reported no meaningful benefits. Additionally, a mitochondrial specialist stated that their patients saw “no real benefit” from SS-31. As a result, the efficacy of SS-31 may differ among individuals.
The Dosage
The daily dosage for SS-31 can be as high as 40mg, but most evidence suggests simply starting a cycle at 4mg/day. The exact quantity necessary may vary depending on the individual. This peptide is administered by injection, often in doses of 0.5 mL.
Clinical trials state that “SS-31 has been found to be well-tolerated when administered as an intravenous infusion in humans, covering a broad dose range from 0.01 mg/kg/h to 0.25 mg/kg/h over a 4-hour period.”
Conclusion
As people age, maintaining cellular health becomes paramount, with mitochondria playing a crucial role. SS-31, a synthetic tetrapeptide, shows promise in safeguarding mitochondria. By binding to cardiolipin, SS-31 shields against oxidative stress, potentially preventing dysfunction and enhancing cellular processes. Research indicates its diverse health benefits, from mitigating inflammation to countering cell apoptosis, marking SS-31 as a potential ally in the pursuit of overall well-being.
FAQ
Can SS-31 Be Used For Anti-Aging Purposes?
Some studies suggest that SS-31 may have potential applications in addressing age-related issues, but conclusive evidence on its effectiveness for anti-aging purposes is still emerging.
In What Conditions Is SS-31 Being Researched or Used?
Research on SS-31 includes its potential applications in conditions associated with mitochondrial dysfunction, neurodegenerative diseases, cardiovascular disorders, and age-related issues.
Is SS-31 Peptide Suitable For All Age Groups?
Since the research on SS-31 is ongoing, its suitability for different age groups is not yet fully established. Consultation with a healthcare professional is recommended to determine its appropriateness for individual cases
How Is SS-31 Administered
SS-31 is administered through injections. Consult a peptide expert to determine the correct dosage and frequency of injections.
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